Scientific publications

A selection of the most recent publications in international scientific journals with impact-factor relating to the research work of the Laboratory of Pharmacognosy and those carried out in collaboration with other research groups


Bottoni, M.; Martinelli, G.; Maranta, N.; Sabato, E.; Milani, F.; Colombo, L.; Colombo, P.S.; Piazza, S.; Sangiovanni, E.; Giuliani, C.; et al. From Primary Data to Ethnopharmacological Investigations on Achillea erba-rotta subsp. moschata (Wulfen) I.Richardson as a Remedy against Gastric Ailments in Valmalenco (Italy). Plants 2024, 13, 539.

Martinelli G, Fumagalli M, Pozzoli C, Nicotra G, Vicentini SF, Maranta N, Sangiovanni E, Dell’Agli M, Piazza S. Exploring In Vitro the Combination of Cistus × incanus L. and Castanea sativa Mill. Extracts as Food Supplement Ingredients against H. pylori Infection. Foods. 2024; 13(1):40.


Martinelli G, Fumagalli M, Piazza S, Maranta N, Genova F, Sperandeo P, Sangiovanni E, Polissi A, Dell’Agli M, De Fabiani E. Investigating the Molecular Mechanisms Underlying Early Response to Inflammation and Helicobacter pylori Infection in Human Gastric Epithelial Cells. International Journal of Molecular Sciences. 2023; 24(20):15147.

Anastasia Van der Auwera, Laura Peeters, Kenn Foubert, Stefano Piazza, Wim Vanden Berghe, Nina Hermans, Luc Pieters. In Vitro Biotransformation and Anti-inflammatory Activity of Constituents and Metabolites of Filipendula ulmaria. Pharmaceutics, 15(4):1291, 2023.

Tesoro C, Lelario F, Ciriello R, Bianco G, Acquavia MA, Montoro P, Crescenzi MA, Gregori E, Dell’Agli M, Piazza S, Guerrieri A, Di Capua A. A validated LC-MS/MS method for quantitative determination of L-dopa in Fagioli di Sarconi beans (Phaseolus vulgaris L.). J Mass Spectrom. 2023 Jul 3:e4952. doi: 10.1002/jms.4952.

Piazza S, Martinelli G, Fumagalli M, Pozzoli C, Maranta N, Giavarini F, Colombo L, Nicotra G, Vicentini SF, Genova F, De Fabiani E, Sangiovanni E, Dell’Agli M. Ellagitannins from Castanea sativa Mill. Leaf Extracts Impair H. pylori Viability and Infection-Induced Inflammation in Human Gastric Epithelial Cells. Nutrients. 2023; 15(6):1504.

Piazza S, Colombo F, Bani C, Fumagalli M, Vincentini O, Sangiovanni E, Martinelli G, Biella S, Silano M, Restani P, Dell’Agli M, Di Lorenzo C. Evaluation of the Potential Anti-Inflammatory Activity of Black Rice in the Framework of Celiac Disease. Foods. 2023; 12(1):63.

Atchan APN, Monthe OC, Tchamgoue AD, Singh Y, Shivashankara ST, Selvi MK, Agbor GA, Magni P, Piazza S, Manjappara UV, Kuiate JR, Dell’Agli M. Anti-Inflammatory, Antioxidant Activities, and Phytochemical Characterization of Edible Plants Exerting Synergistic Effects in Human Gastric Epithelial Cells. Antioxidants (Basel). 2023 Feb 27;12(3):591. doi: 10.3390/antiox12030591.


Piazza S, Fumagalli M, Martinelli G, Pozzoli C, Maranta N, Angarano M, Sangiovanni E, Dell’Agli M. Hydrolyzable Tannins in the Management of Th1, Th2 and Th17 Inflammatory-Related Diseases. Molecules. 2022; 27(21):7593.

Piazza S, Martinelli G, Magnavacca A, Fumagalli M, Pozzoli C, Terno M, Canilli L, Angarano M, Maranta N, Dell’Agli M, Sangiovanni E. Unveiling the Ability of Witch Hazel (Hamamelis virginiana L.) Bark Extract to Impair Keratinocyte Inflammatory Cascade Typical of Atopic Eczema. International Journal of Molecular Sciences. 2022; 23(16):9279.

Piazza S, Martinelli G, Vrhovsek U, Masuero D, Fumagalli M, Magnavacca A, Pozzoli C, Canilli L, Terno M, Angarano M, Dell’Agli M, Sangiovanni E. Anti-Inflammatory and Anti-Acne Effects of Hamamelis virginiana Bark in Human Keratinocytes. Antioxidants. 2022; 11(6):1119.

Martinelli G, Angarano M, Piazza S, Fumagalli M, Magnavacca A, Pozzoli C, Khalilpour S, Dell’Agli M, Sangiovanni E. The Nutraceutical Properties of Sumac (Rhus coriaria L.) against Gastritis: Antibacterial and Anti-Inflammatory Activities in Gastric Epithelial Cells Infected with H. pylori. Nutrients. 2022; 14(9):1757.

Melzi G, Marabini L, Marinovich M, Dell’Agli M, Piazza S, Lombardo G, Donetti E. Photoprotective properties of Vitis vinifera L. leaves extract on UVA-induced damage in human endothelial cells (EA.hy926 cells). Photodermatol Photoimmunol Photomed. 2021 Mar;37(2):171-174. doi: 10.1111/phpp.12628.

Magnavacca, A, Sangiovanni, E, Racagni, G, Dell’Agli, M. The antiviral and immunomodulatory activities of propolis: An update and future perspectives for respiratory diseases. Med Res Rev. 2022; 42: 897- 945.

Martinelli G, Magnavacca A, Fumagalli M, DellʼAgli M, Piazza S, Sangiovanni E. Cannabis sativa and Skin Health: Dissecting the Role of Phytocannabinoids. Planta Med. 2022 Jun;88(7):492-506. doi: 10.1055/a-1420-5780.

Nwakiban Atchan AP, Shivashankara ST, Piazza S, Tchamgoue AD, Beretta G, Dell’Agli M, Magni P, Agbor GA, Kuiaté JR, Manjappara UV. Polyphenol-Rich Extracts of Xylopia and Aframomum Species Show Metabolic Benefits by Lowering Hepatic Lipid Accumulation in Diet-Induced Obese Mice. ACS Omega. 2022 Mar 30;7(14):11914-11928. doi: 10.1021/acsomega.2c00050.

Agbor GA, Dell’Agli M, Kuiate JR, Ojo O. Editorial: The Role of Medicinal Plants and Natural Products in Modulating Oxidative Stress and Inflammatory Related Disorders. Front Pharmacol. 2022 Jun 24;13:957296. doi: 10.3389/fphar.2022.957296.

Mottarlini F, Fumagalli M, Castillo-Díaz F, Piazza S, Targa G, Sangiovanni E, Pacchetti B, Sodergren MH, Dell’Agli M, Fumagalli F, Caffino L. Single and Repeated Exposure to Cannabidiol Differently Modulate BDNF Expression and Signaling in the Cortico-Striatal Brain Network. Biomedicines. 2022 Aug 1;10(8):1853. doi: 10.3390/biomedicines10081853.

Tesoro C, Ciriello R, Lelario F, Di Capua A, Pascale R, Bianco G, Dell’Agli M, Piazza S, Guerrieri A, Scrano L, Bufo SA, Acquavia MA. Development and Validation of a Reversed-Phase HPLC Method with UV Detection for the Determination of L-Dopa in Vicia faba L. Broad Beans. Molecules. 2022; 27(21):7468.


Barani M, Sangiovanni E, Angarano M, Rajizadeh MA, Mehrabani M, Piazza S, Gangadharappa HV, Pardakhty A, Mehrbani M, Dell’Agli M, Nematollahi MH. Phytosomes as Innovative Delivery Systems for Phytochemicals: A Comprehensive Review of Literature. Int J Nanomedicine. 2021;16:6983-7022

Di Cesare Mannelli L, Palma Esposito F, Sangiovanni E, Pagano E, Mannucci C, Polini B, Ghelardini C, Dell’Agli M, Izzo AA, Calapai G, de Pascale D, Nieri P. Pharmacological Activities of Extracts and Compounds Isolated from Mediterranean Sponge Sources. Pharmaceuticals. 2021; 14(12):1329.

Magnavacca A, Piazza S, Cammisa A, Fumagalli M, Martinelli G, Giavarini F, Sangiovanni E, Dell’Agli M. Ribes nigrum Leaf Extract Preferentially Inhibits IFN-γ-Mediated Inflammation in HaCaT Keratinocytes. Molecules. 2021; 26(10):3044.

Donatella Canistro, Annalisa Chiavaroli, Donatella Cicia, Francesco Cimino, Diego Currò, Mario Dell’Agli, Claudio Ferrante, Lisa Giovannelli, Sheila Leone, Giulia Martinelli, Luigi Milella, Ester Pagano, Stefano Piazza, Maria Ponticelli, Lucia Recinella, Sara Ristori, Enrico Sangiovanni, Antonella Smeriglio, Antonio Speciale, Domenico Trombetta, Fabio Vivarelli. The pharmacological basis of the curcumin nutraceutical uses: an update. Pharmadvances. 3 (2), June 2021

Atchan Nwakiban AP, Passarelli A, Da Dalt L, Olivieri C, Demirci TN, Piazza S, Sangiovanni E, Carpentier-Maguire E, Martinelli G, Shivashankara ST, Manjappara UV, Tchamgoue AD, Agbor GA, Kuiate JR, Daglia M, Dell’Agli M, Magni P. Cameroonian Spice Extracts Modulate Molecular Mechanisms Relevant to Cardiometabolic Diseases in SW 872 Human Liposarcoma Cells. Nutrients. 2021 Nov 26;13(12):4271. doi: 10.3390/nu13124271.

Melzi G, Marabini L, Marinovich M, Dell’Agli M, Piazza S, Lombardo G, Donetti E. Photoprotective properties of Vitis vinifera L. leaves extract on UVA-induced damage in human endothelial cells (EA.hy926 cells). Photodermatol Photoimmunol Photomed. 2021 Mar;37(2):171-174. doi: 10.1111/phpp.12628.

Sangiovanni E, Dell’Agli M. Special Issue: Anti-Inflammatory Activity of Plant Polyphenols 2.0. Biomedicines. 2021 Dec 24;10(1):37. doi: 10.3390/biomedicines10010037.

Méndez D, Escalona-Arranz JC, Foubert K, Matheeussen A, Van der Auwera A, Piazza S, Cuypers A, Cos P, Pieters L. Chemical and Pharmacological Potential of Coccoloba cowellii, an Endemic Endangered Plant from Cuba. Molecules. 2021 Feb 10;26(4):935. doi: 10.3390/molecules26040935.


Nwakiban APA, Fumagalli M, Piazza S, Magnavacca A, Martinelli G, Beretta G, Magni P, Tchamgoue AD, Agbor GA, Kuiaté J-R, Dell’Agli M, Sangiovanni E. Dietary Cameroonian Plants Exhibit Anti-Inflammatory Activity in Human Gastric Epithelial Cells. Nutrients. 2020; 12(12):3787.

Sbrini G, Brivio P, Sangiovanni E, Fumagalli M, Racagni G, Dell’Agli M, Calabrese F. Chronic Treatment with a Phytosomal Preparation Containing Centella asiatica L. and Curcuma longa L. Affects Local Protein Synthesis by Modulating the BDNF-mTOR-S6 Pathway. Biomedicines. 2020; 8(12):544.

Piazza S, Fumagalli M, Khalilpour S, Martinelli G, Magnavacca A, Dell’Agli M, Sangiovanni E. A Review of the Potential Benefits of Plants Producing Berries in Skin Disorders. Antioxidants. 2020; 9(6):542.

Nozza E, Melzi G, Marabini L, Marinovich M, Piazza S, Khalilpour S, Dell’Agli M, Sangiovanni E. Rhus coriaria L. Fruit Extract Prevents UV-A-Induced Genotoxicity and Oxidative Injury in Human Microvascular Endothelial Cells. Antioxidants. 2020; 9(4):292.

Marabini L, Melzi G, Lolli F, Dell’Agli M, Piazza S, Sangiovanni E, Marinovich M. Effects of Vitis vinifera L. leaves extract on UV radiation damage in human keratinocytes (HaCaT). J Photochem Photobiol B. 2020 Mar;204:111810. doi: 10.1016/j.jphotobiol.2020.111810.

Sbrini G, Brivio P, Fumagalli M, Giavarini F, Caruso D, Racagni G, Dell’Agli M, Sangiovanni E, Calabrese F. Centella asiatica L. Phytosome Improves Cognitive Performance by Promoting Bdnf Expression in Rat Prefrontal Cortex. Nutrients. 2020 Jan 29;12(2):355. doi: 10.3390/nu12020355.

Nwakiban APA, Cicolari S, Piazza S, Gelmini F, Sangiovanni E, Martinelli G, Bossi L, Carpentier-Maguire E, Tchamgoue AD, Agbor G, Kuiaté JR, Beretta G, Dell’Agli M, Magni P. Oxidative Stress Modulation by Cameroonian Spice Extracts in HepG2 Cells: Involvement of Nrf2 and Improvement of Glucose Uptake. Metabolites. 2020 May 1;10(5):182. doi: 10.3390/metabo10050182.

Galimberti A, Cena H, Campone L, Ferri E, Dell’Agli M, Sangiovanni E, Belingheri M, Riva MA, Casiraghi M, Labra M. Rethinking Urban and Food Policies to Improve Citizens Safety After COVID-19 Pandemic. Front Nutr. 2020 Oct 8;7:569542. doi: 10.3389/fnut.2020.569542.

Berenguer-Rivas CA, Escalona-Arranz JC, Llauradó-Maury G, Van der Auwera A, Piazza S, Méndez-Rodríguez D, Foubert K, Cos P, Pieters L. Anti-inflammatory effect of Adelia ricinella L. aerial parts. J Pharm Pharmacol. 2021 Mar 8;73(4):553-559. doi: 10.1093/jpp/rgaa057


Khalilpour S, Sangiovanni E, Piazza S, Fumagalli M, Beretta G, Dell’Agli M. In vitro evidences of the traditional use of Rhus coriaria L. fruits against skin inflammatory conditions. J Ethnopharmacol. 2019 Jun 28;238:111829.

Piazza S, Pacchetti B, Fumagalli M, Bonacina F, Dell’Agli M, Sangiovanni E. Comparison of Two Ginkgo biloba L. Extracts on Oxidative Stress and Inflammation Markers in Human Endothelial Cells. Mediators Inflamm. 2019 Jun 25;2019:6173893.

Sangiovanni E, Fumagalli M, Pacchetti B, Piazza S, Magnavacca A, Khalilpour S, Melzi G, Martinelli G, Dell’Agli M. Cannabis sativa L. extract and cannabidiol inhibit in vitro mediators of skin inflammation and wound injury. Phytother Res. 2019 Aug;33(8):2083-2093.

Sangiovanni E, Fumagalli M, Santagostini L, Forino M, Piazza S, Colombo E, Taglialatela-Scafati O, Fico G, Dell’Agli M. (2019). A bio-guided assessment of the anti-inflammatory activity of hop extracts (Humulus lupulus L. cv. Cascade) in human gastric epithelial cells. Journal of Functional Foods. 57. 95-

Sangiovanni E, Di Lorenzo C, Piazza S, Manzoni Y, Brunelli C, Fumagalli M, Magnavacca A, Martinelli G, Colombo F, Casiraghi A, Melzi G, Marabini L, Restani P, Dell’Agli M. Vitis vinifera L. Leaf Extract Inhibits In Vitro Mediators of Inflammation and Oxidative Stress Involved in Inflammatory-Based Skin Diseases. Antioxidants. 2019; 8(5):134.

Colombo F, Di Lorenzo C, Regazzoni L, Fumagalli M, Sangiovanni E, Peres de Sousa L, Bavaresco L, Tomasi D, Bosso A, Aldini G, Restani P, Dell’Agli M. Phenolic profiles and anti-inflammatory activities of sixteen table grape (Vitis vinifera L.) varieties. Food Funct. 2019 Apr 17;10(4):1797-1807.

D’Alessandro S, Magnavacca A, Perego F, Fumagalli M, Sangiovanni E, Prato M, Dell’Agli M, Basilico N. Effect of Hypoxia on Gene Expression in Cell Populations Involved in Wound Healing. Biomed Res Int. 2019 Aug 22;2019:2626374. doi: 10.1155/2019/2626374.

Franco AM, Tocci N, Guella G, Dell’Agli M, Sangiovanni E, Perenzoni D, Vrhovsek U, Mattivi F, Manca G. Myrtle Seeds (Myrtus communis L.) as a Rich Source of the Bioactive Ellagitannins Oenothein B and Eugeniflorin D2. ACS Omega. 2019 Sep 20;4(14):15966-15974. doi: 10.1021/acsomega.9b02010.

Atchan Nwakiban AP , Sokeng AJ , Dell’Agli M , Bossi L , Beretta G , Gelmini F , Deutou Tchamgoue A , Agbor Agbor G , Kuiaté JR , Daglia M , Magni P . Hydroethanolic plant extracts from Cameroon positively modulate enzymes relevant to carbohydrate/lipid digestion and cardio-metabolic diseases. Food Funct. 2019 Oct 16;10(10):6533-6542. doi: 10.1039/c9fo01664c.